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Latest Research Articles From JNNP


    • Guillain-Barre syndrome: looking back… and forward

      This editorial comments on a large prospective study of GBS in which a second course of intravenous immunoglobulin was unhelpful In 1988, in the first large-scale prospective study of Guillain-Barré syndrome (GBS), John Winer and colleagues collected and followed 100 patients from the London area.1 A year later, 20% of the patients were still unable to walk, and an additional 13% had died, …

     

     

    • Is the future of symptomatic intracranial atherosclerotic stenosis management promising?

      Intracranial atherosclerotic stenosis (ICAS) is one of most common causes of stroke; it has the highest rate of recurrence compared with other aetiologies.1 ICAS is especially more prevalent among the Asians.2 The results of the Chinese Intracranial Atherosclerosis Study indicated that the prevalence of symptomatic ICAS (sICAS) is as high as 46%.1 The 1-year stroke recurrence rate with sICAS is re …

     

    • In vivo tracking of TDP43 in ALS: cognition as a new biomarker for brain pathology

      The thought-provoking hypothesis has been empirically tested that cognitive deficits may be an indirect measure of cortical pTDP43 neuropathology There is a lack of in vivo readout measures to track changes in brain pathology during the course of amyotrophic lateral sclerosis (ALS) which might support the measurement of therapeutic effects in clinical trials. For this, biomarkers need to be specif …

     

    • Genetic variants in incident SUDEP cases from a community-based prospective cohort with epilepsy

      Objective Sudden unexpected death in epilepsy (SUDEP) is a leading cause of epilepsy-related mortality in young adults. It has been suggested that SUDEP may kill over 20 000 people with epilepsy in China yearly. The aetiology of SUDEP is unclear. Little is known about candidate genes for SUDEP in people of Chinese origin as most studies have ascertained this in Caucasians. No candidate genes for S …