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Latest Research Articles From JNNP


    • Atrial fibrillation and FLAIR/T2 white matter hyperintensities on MRI

      Atrial fibrillation (AF) related embolism does not contribute to leukoaraiosis but AF-related perfusion changes might, by aggravating chronic microangiopathic ischemia. White matter disease, also termed leukoaraiosis, is an established marker of cerebral small vessel disease load in older adults and it is an important predictor of incident stroke, cognitive impairment and poor outcomes after a str …

     

    • Diet and disease modification in multiple sclerosis: a nutritional epidemiology perspective

      A discussion of the role of diet in disease course in pediatric multiple sclerosis and additional considerations relevant to the design and conduct of observational nutritional epidemiology studies. The prognosis of multiple sclerosis (MS) is generally quite heterogeneous. Several environmental influences like vitamin D status and smoking have been consistently linked with disease course; how …

     

    • Non-invasive in vivo neuropathology of the C9orf72-related ALS-FTD syndrome

      Diffusion tensor imaging to stratify a clinically heterogeneous multi-system cerebral neurodegenerative syndrome The unmistakeable neurodegenerative disease amyotrophic lateral sclerosis (ALS) is a common clinical endpoint for an expanding range of upstream cellular pathway derangements.1 Clinical, genetic and molecular signatures shared with frontotemporal dementia (FTD) have rendered the br …