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Latest Research Articles From JNNP


     

    • CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD

      Objective To investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer’s disease (AD), and associated with neuronal degeneration in brain tissue. Methods CSF neurogranin, total tau, neurofilament light (NFL) and 14-3-3 protein were measured in neurological controls (NCs, n=64), AD (n=46) and …

     

     

    • Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes

      Objective A hallmark of amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase-1 (SOD1) are inclusions containing SOD1 in motor neurons. Here, we searched for SOD1-positive inclusions in 29 patients carrying ALS-linked mutations in six other genes. Methods A panel of antibodies that specifically recognise misfolded SOD1 species were used for immunohistochemical investigati …

     

    • Neurofilament light chain as a biomarker in neurological disorders

      In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal dam …