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Latest Research Articles From JNNP


    • Atypical chronic inflammatory demyelinating polyneuropathies

      We need greater vigilance, with more rigid or standard criteria for atypical CIDP Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy progressive for more than 2 months, including several clinical subtypes.1 2 In 1975, Dyck et al3 described the classical prototype of CIDP, and emphasised that a prominent clinical feature is weakness of the proximal and distal …

     

    • The reunification of amyotrophic lateral sclerosis

      ALS is the unifying term for this heterogeneous syndrome and time to question the dogma forged at El Escorial Historically characterised as a neuromuscular disease involving progressive loss of both central and peripheral motor neurons, amyotrophic lateral sclerosis (ALS) now sits among the cerebral neurodegenerative syndromes, involving clinical, pathological and genetic overlap with frontotempor …

     

    • New teased-fibre definitions represent specific mechanisms of neuropathy

      New definitions will increase the significance of teased-fibre studies from both pathophysiological and diagnostic viewpoints Although nerve biopsy is a classical approach, it still plays a role in the diagnosis and elucidation of the pathophysiology of neuropathy.1 There are two major techniques used to assess the morphology of nerve fibres in the longitudinal direction; one involves cutting glut …

     

     

    • Proposal of new clinical diagnostic criteria for POEMS syndrome

      Objective To propose the optimal diagnostic criteria for polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome using appropriate statistical methods and disease controls. Methods This retrospective cohort study included 104 consecutive patients with suspected POEMS syndrome, among whom a gold standard group of 60 patients with definitive POEMS syndrome diagnosis …